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Dabrafenib Mesylate
| CAS No. | 1195768-06-9 |
| Purity | 99% |
| Formular | C24H24F3N5O5S3 |
| EINECS No. | 209-812-1 |
| Molecular Weight | 615.67 |
| Storage | 4°C, sealed storage, away from moisture |
| Appearance | Solid, White to off-white |
| Solvent | DMSO |
| Application | Pharmaceuticals |
| Max Conc. mg/mL | 30.78 |
(Synonyms: GSK2118436 Mesylate; GSK 2118436B)
Description: Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome
Chemical Name: N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonate
Purity: ≥98% (HPLC)
Biological Activity for Dabrafenib mesylate
Dabrafenib mesylate is a potent and selective Raf kinase inhibitor (IC50 values are 0.8, 3.2 and 5.0 nM for B-RafV600E, wild-type B-Raf and c-Raf, respectively). Exhibits selectivity for B-Raf over a panel of 270 other kinases. Arrests cell cycle in the G1 phase and inhibits growth of B-RafV600E mutant melanoma and colon cancer cells in vitro and in vivo. Orally bioavailable. Also inhibits NEK9 (IC50 <10 nM) and CDK16. Identified as targeting human host proteins that interact with SARS-CoV-2.
Technical Data for Dabrafenib mesylate
| M. Wt | 615.66 |
| Formula | C23H20F3N5O2S2.CH3SO3H |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1195768-06-9 |
| PubChem ID | 44516822 |
| InChI Key | YKGMKSIHIVVYKY-UHFFFAOYSA-N |
| Smiles | CS(O)(=O)=O.CC(C)(C1=NC(C2=C(C(NS(=O)(C3=C(C=CC=C3F)F)=O)=CC=C2)F)=C(C4=NC(N)=NC=C4)S1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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